Q: Dose adjustement may be required for Precedex (Dexmedetomidine) in
A) Renal failure
B) liver failure
C) ARDS
D) Thrombocytopenia
E) Seizure disorder

Answer: Liver failure

 

Dexmedetomidine wears off clinically in approximately 6 minutes in adults, but it is extensively distributed with high protein binding. It is mostly metabolized through both the cytochrome P450 enzyme system and direct glucuronidation. It has a terminal elimination half-life of approximately 2 hours. Dose reduction may be needed in patients with hepatic dysfunction.