Q: Concurrentt use of which medications may exacerbate risk of adrenal insufficiency from Etomidate?




Answer: Opioids or benzodiazepines


At least 2 studies showed that concurrent use of etomidate with opioids and/or benzodiazepines may to exacerbate etomidate related adrenal insufficiency. However, solid evidence is lacking.


Daniell, Harry (2008). "Opioid and benzodiazepine contributions to etomidate-associated adrenal insufficiency". Intensive Care Medicine 34: 2117–8.


Daniell, HW (2008). "Opioid contribution to decreased cortisol levels in critical care patients.". Arch Surg 143 (12): 1147-1148.