Fidaxomicin - new antibiotic for C.diff.

Fidaxomicin (Dificid) is a non-systemic bactericidal with demonstrated selective eradication of Clostridium difficile. Interestingly, it causes minimal disruption of normal healthy intestinal flora. Obviously, It is administered orally.

Mechanism of action: It works by inhibiting the bacterial enzyme RNA polymerase, resulting in the death of Clostridium difficile.

Studies have shown that it is as effective as oral vancomycin (92.1% vs. 89.8%) but with less recurrence of C. Diff. Colitis (13.3% vs 24.0%).

Dose is 200 mg twice a day for 10 days